N-(m-PEG9)-N'-(PEG5-acid)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 2107273-26-5

Molecular Weight: 1093.77

Formula: C57H89ClN2O16

Chemical Name: 1-(17-carboxy-3,6,9,12,15-pentaoxaheptadecan-1-yl)-2-{5-[3,3-dimethyl-1-(2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl)-2,3-dihydro-1H-indol-2-ylidene]penta-1,3-dien-1-yl}-3,3-dimethyl-3H-indol-1-ium chloride

Smiles: [Cl-].COCCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=CC=CC=CC2=[N+](CCOCCOCCOCCOCCOCCC(O)=O)C3=CC=CC=C3C2(C)C)C(C)(C)C2=CC=CC=C12

InChiKey: UGQMQMLGHBYOHY-UHFFFAOYSA-N

InChi: InChI=1S/C57H88N2O16.ClH/c1-56(2)49-13-9-11-15-51(49)58(20-23-64-28-31-68-36-39-71-38-35-67-30-27-63-22-19-55(60)61)53(56)17-7-6-8-18-54-57(3,4)50-14-10-12-16-52(50)59(54)21-24-65-29-32-69-37-40-72-43-44-74-47-48-75-46-45-73-42-41-70-34-33-66-26-25-62-5;/h6-18H,19-48H2,1-5H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.